Isaac Gallegos
Research Engineer · Harvard Medical School
I build optical systems and computational methods that extract diagnostic information from light–tissue interactions at the Wellman Center for Photomedicine. My work spans spectroscopic intravascular OCT, NIR-II photoacoustic imaging, and inverse algorithms — grounded in physics-first principles and aimed at clinically translatable tools.
Selected work
All projects →Extracting wavelength-dependent tissue optical properties from broadband OCT signals for quantitative coronary artery characterization without additional imaging modalities.
Wellman Center for Photomedicine, MGH / Harvard Medical School NIR-II Photoacoustic ImagingLabel-free molecular imaging using a first-of-its-kind all-fiber laser amplifier operating in the 1064nm band with spectral unmixing algorithms for deep tissue characterization.
Wellman Center for Photomedicine, MGH / Harvard Medical SchoolResearch interests
I develop computational and optical methods for biological tissue characterization, working at the intersection of biophotonics, inverse problems, and quantum sensing. My current work focuses on extracting molecular composition from OCT interferograms and developing multi-spectral photoacoustic systems for label-free molecular imaging. I am interested in how physics-informed computational methods — from inverse design to differentiable simulation — can push the fundamental limits of what optical instruments can measure.
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